Tissue Microarrays for Analysis of Expression - Diva Portal

Molecular understanding of KRAS- and BRAF - DiVA Portal

Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some 2019-07-05 · 1. Anticancer Agents Med Chem. 2019 Jul 5. doi: 10.2174/1871520619666190705121614. [Epub ahead of print] Dehydroandrographolide Inhibits Osteosarcoma Cell Growth and Metastasis by Targeting SATB2-Mediated EMT. CONCLUSIONS: SATB2 plays an important role in regulating osteosarcoma stem cell-like properties and tumor growth.

Satb2 osteosarcoma

SATB2 was a very sensitive marker for osteosarcoma: 100% on whole slides, and 94%, including tissue micro-array (TMA) data, as reported by David and Horvai. These results are also analogous to the findings published previously by Connor and Hornick, who report a 98% sensitivity of this marker for staining osteosarcomas. SATB2 plays an important role in regulating osteosarcoma stem cell-like properties and tumor growth. The combination of conventional chemotherapy and metformin may be a promising therapeutic strategy for osteosarcoma patients. Conclusion: SATB2 is a reliable osteoblastic marker for differential diagnosis of osteosarcoma and non-osteoid sarcoma, although with a limited role in separating osteosarcoma from non-malignant osteoblastic lesions. SATB2 is commonly expressed in osteosarcomas. Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma (SCO) and other small round cell tumors of bone, for instance Ewing sarcoma family of tumors (ESFT), it has not been tested in a large series of ESFT and chondrosarcomas so far.

Molecular understanding of KRAS- and BRAF - DiVA Portal

Promotes Viability and Inhibits Apoptosis of Osteosarcoma Cells by Activating Value of SATB2 Immunostaining in the Distinction Between Small Intestinal inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Hälsa och samhälle PROGNOSTISK SIGNIFIKANS AV SATB1 OCH SATB2 Reduction of SATB2 or N-cadherin resulted in NF-κB inactivation, which led to impaired osteosarcoma sphere formation and tumor cell proliferation [54]. SATB2 is a marker of osteoblastic differentiation in benign and malignant mesenchymal tumours. Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some settings, particularly in the distinction between hyalinized collagen and osteoid.

Tumörmikromiljö - Forskningsoutput - Lunds universitet

SATB2 is commonly expressed in osteosarcomas. Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma (SCO) and other small round cell tumors of Osteosarcoma and Its Variants Osteosarcomas (also known as osteogenic sarcoma) are malignant neoplasms of bone that are composed of proliferating cells that produce osteoid, at least focally.

osteoblasts and malignant osteoids IHC:SATB2 and AKP are positive, TP53 alteration and MDM2 amplification Feb 2, 2021 Metformin reduces SATB2-mediated osteosarcoma stem cell-like phenotype and tumor growth via inhibition of N-cadherin/NF-kB signaling. SATB2 and pluripotency-associated gene expression in osteosarcoma CSCs were analyzed using. qRT-PCR and Western blotting. The sphere for- mation assay, SATB2 is commonly expressed in osteosarcomas. Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma In the present study, we describe the expression profile of lncRNAs in osteosarcomas compared with paired adjacent non-cancerous tissue (n=7) using microarray Histochemical staining of alkaline phosphatase can demonstrate the osteoblastic nature of the tumor.
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These results are also analogous to the findings published previously by Connor and Hornick, who report a 98% sensitivity of this marker for staining osteosarcomas. SATB2 plays an important role in regulating osteosarcoma stem cell-like properties and tumor growth. The combination of conventional chemotherapy and metformin may be a promising therapeutic strategy for osteosarcoma patients.

SATB2-AS1 was reported as overexpressed in osteosarcoma, and was associated with increased cell proliferation and growth .
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Osteosarkom （OS） - Kunskap - Wuhan Healthcare Biotechnology

To distinguish small cell osteosarcoma from other primary small cell malignancies of bone, we evaluated the immunohistochemical (IHC) expression of CD99 and SATB2, a marker of osteoblastic differentiation. Feb 11, 2021 Bone - Osteosarcoma - general. Negative for SATB2; Contains a characteristic gene rearrangement (EWSR1-ETS transcription factor).

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DiVA - Sökresultat - DiVA Portal

2020-01-31 · The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent osteosarcoma. Ying T(1), Dong JL(2), Yuan C(1), Li P(2), Guo Q(1). Author information: (1)Trauma Center, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Army Medical University, No.10 ChangjiangZhi Road, Yuzhong District, Chong The SATB2-AS1 is a 3197-bp lncRNA on chromosome 2. This is the first report, where we have documented the increased expression of SATB2-AS1 in osteosarcoma patients and in human osteosarcoma cancer cell lines (U2OS, HOS, MG63). SATB2-AS1 expression was significantly higher in the metastatic tumors compared to non-metastatic tumors.